Negative regulation of nuclear factor-kappaB activation and function by glucocorticoids
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چکیده
منابع مشابه
REVIEW Negative regulation of nuclear factor- B activation and function by glucocorticoids
Glucocorticoids (GCs) exert their anti-inflammatory and antiproliferative effects principally by inhibiting the expression of cytokines and adhesion molecules. Mechanistically, GCs diffuse through the cell membrane, and bind to their inactive cytosolic receptors (GRs), which then undergo conformational modifications that allow for their nuclear translocation. In the nucleus, activated GRs modul...
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2002
ISSN: 0952-5041,1479-6813
DOI: 10.1677/jme.0.0280069